PPP1R13B Antibody, FITC conjugated

1. results provide new insights into EGR-1/ASPP1 regulatory loop in sensitizing Quercetin-induced apoptosis. EGR-1/ASPP1, therefore, may be potentially used as therapeutic targets to improve cancer's response to pro-apoptosis treatments. PMID: 28594407
2. Results showed that the protein expression levels of ASPP1 in esophageal squamous cell carcinoma (ESCC) tissues and in paired noncancerous tissues were similar but was significantly associated with histological differentiation and invasive depth which suggest that it might be involved in the progression of ESCC. PMID: 28103919
3. ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments. PMID: 26595804
4. ASPP1 and ASPP2 cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53. PMID: 23392125
5. the mRNA expression of ASPP1 and ASPP2 was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 PMID: 22552744
6. ASPP1 promoter methylation may be associated with the malignant progression of non-small cell lung cancer, and ASPP1 expression promotes cellular apoptosis. PMID: 22169642
7. The ability of ASPP1 to activate YAP results in the decreased expression of LATS2, which lowers the ability of p53 to induce p21, cell-cycle arrest and senescence. PMID: 22068052
8. overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F pathway PMID: 21479363
9. Suggest that downregulation of ASPP1 by hypermethylation may be involved in the pathogenesis and progress of gestational trophoblastic disease, probably through its effect on apoptosis. PMID: 21102414
10. Data show that Lats2 and ASPP1 shunt p53 to proapoptotic promoters and promote the death of polyploid cells. PMID: 21041410
11. ASPP1 and ASPP2 genes are frequently down-regulated by DNA methylation in HBV-positive hepatocellular carcinoma, which may play important roles in the development of HCC PMID: 20034025
12. target of E2F transcription factor PMID: 15731768
13. ASPP1 CpG island aberrant methylation could be one molecular and genetic alteration in wild-type p53 tumours. PMID: 15757645
14. Mdm2 and mdmx prevent ASPP1 and ASPP2 from stimulating the apoptotic function of p53 by binding and inhibiting the transcriptional activity of p53. PMID: 15782125
15. results demonstrate that decreased expression of ASPP1 in patients with ALL is due to an abnormal methylation of its promoter and is associated with a poor prognosis PMID: 16314841

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HGNC: 14950

OMIM: 606455

KEGG: hsa:23368

STRING: 9606.ENSP00000202556

UniGene: Hs.709297